NIMG-109. A PILOT STUDY OF LYMPHOSCINTIGRAPHY WITH TRACER INJECTION IN THE HUMAN BRAIN

Abstract INTRODUCTION Many groups have reported lymphatic and glymphatic structures in animal human brains, but tracer injection into the brain to demonstrate real-time drainage mapping has not been reported. Technetium (99mTc) tilmanocept is a radiopharmaceutical agent that binds CD206 maps draining lymph nodes. We hypothesized peritumoral 99mTc-tilmanocept parenchyma would map cervical Here we show paucity of movement after due presumed inefficiency drainage. METHODS enrolled 14 patients undergoing resection or stereotactic biopsy suspected benign malignant intracranial tumors. Patients received injections followed by planar tomographic imaging. One patient was excluded from analysis because leakage during injection. RESULTS No showed regional On average, correcting for radioactive decay, 70.1% (95% CI: 60.0%, 81.6%) site 78.1% 71.1%, 85.1%) whole-head on day surgery remained morning after, with variable radioactivity subarachnoid space. The remaining fraction at much larger than expected 1.12% 1.07%, 1.17%) based previously clearance rates non-brain injections. determined this lack sequestration large population CD206+ cells via immunohistochemistry tissue sections. tumors who underwent minimally invasive all no DISCUSSION In pilot study, injected parenchyma, there an absence Our work demonstrates highlights opportunity improve immunosurveillance.